comparative analyses of villin and her-2 genes expression in breast cancer
نویسندگان
چکیده
background: it has been previously demonstrated that her-2 (human epidermal growth factor receptor 2) positive breast cancers are associated with an aggressive nature. villin is an actin bundling protein that plays a key role in actin reorganization and cell remodeling during stress. in this study, we aimed to investigate the correlation of villin gene expression with her-2 in breast cancer patients. methods: samples of 42 patients with breast cancer, and 3 controls were collected. expression of villin and her-2 genes were monitored with real-time pcr using pre-designed primers. student t-test was used to compare the means between the groups. results: the mean age of the patients was 50±4.11years. expression of the villin gene was decreased in 28 samples (18 and 10 samples with negative and strongly her-2 positive, respectively). villin gene expression was increased in 14 samples (7, 2 and 5 samples with negative, weakly positive, and strongly her-2 positive, respectively). the expression of villin was significantly correlated with her-2 positive status (p = 0.00057) conclusions: we found that villin gene expression is associated with her-2 positivity and may be a predicting factor in aggressive breast cancer.
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عنوان ژورنال:
archives of breast cancerجلد ۲، شماره ۴، صفحات ۱۲۰-۱۲۴
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